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Key Ingredient

USFP's KEY INGREDIENT

The latest research indicates that a balance of minerals proteins and carbohydrates when when working together, have a profound effect in regulating bone formation and bone resorption process.

USFP's patented organic matrix contains high level of calcium and other minerals in a balanced mineral profile as naturally present in bone. A USFP patented manufacturing process ensures that the calcium and other minerals in USFP's key ingredient have the same bioavailability as found in milk. USFP's patented ingredient also contains vital organic source proteins and phosphopeptides.

Essential Proteins

A fraction of organic sourced proteins has been shown to increase the number of bone-forming osteoblasts and regulates the activity of bone-destroying osteoclasts; therefore it vitalizes the bone itself by promoting bone formation, while inhibiting excess bone resorption.

An in vivo study of essential organic protein (ESP) found that the bones of rats treated with these ESP's had a higher breaking energy than control rats, the BMD was higher in the group than the control group, and urinary deoxypyridinoline excretion was lower in the ESP group. “These results suggest that ESP suppresses the osteoclast-mediated bone resorption and prevents bone loss caused by ovariectomy.” The follow-up in vitro study showed that ESP dose-dependently suppressed the number of pits formed by these osteoclasts, indicating that ESP suppresses bone resorption by its direct effects on osteoclasts. (Toba 2000 p403-8)

Additionally, human clinical trials suggest that ESP promoted bone formation and suppressed bone resorption, while maintaining the balance of bone remodeling. In a Japanese study, 30 normal adult healthy men were given experimental beverages containing milk basic protein (ESP) for 16 days, during which time the participants' serum osteocalcin concentration increased significantly. Urinary NTx excretion decreased significantly and was related to the serum osteocalcin concentration. NTx is reportedly more sensitive to a change in bone metabolism than deoxypyridinoline. (Toba et. Al, 2001, p 1353-1357)

In healthy women, randomized placebo trials of ESP supplementation have measured BMD and serum and urine indices of bone metabolism. Both trials showed a mean rate of left calcaneus BMD gain of women in the MBP group significantly higher than in the placebo group. Because NTx significantly decreased in the ESP group compared to placebo, one mechanism is likely inhibition of osteoclast-mediated bone resorption. These six-month trials indicate that long-term daily ESP supplementation of 40 mg could significantly increase BMD. (Aoe et. Al, 2001 pp. 913-918, Yamamura 2002, 702-4)

Phosphopeptides (PP)

PP binds with calcium and other minerals in human digestive system therefore enhances its absorption in the intestine.

In a study of chicks, PPs were capable of stimulating the duodenal absorption of radiocalcium and its transfer to body in vivo. In that study, PPs were able to stimulate calcium metabolism without vitamin D. (Meisel and Bockelmann, 212; Vegarud, Langsrud, Svenning; Mykkänen and Wasserman, 1980) A review of studies of the effects of PPs on mineral and trace element metabolism indicated that phosphopeptides revealed positive effects on mineral solubility and absorbability and bone mineralization under short-term and in vitro experimental conditions. (Scholz-Ahrens and Schrezenmeir)

Element

USFP KEY INGREDIENT

Bone Mineral
Analysis

Calcium (Ca)

26.0%

25%

Phosphorus (P)

15.5%

12%

Magnesium (Mg)

1.5%

0.37%

Potassium (K)

0.5%

0.5%

Zinc (Zn)

15 ppm

9 ppm

Iron (Fe)

26 ppm

21 ppm

Manganese (Mn)

1.5 ppm

1.2 ppm

Copper (Cu)

3.2 ppm

0.5 ppm





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